Multiple Sclerosis – Sex Hormones

The National Multiple Sclerosis society said, “There is a growing body of scientific evidence suggesting that hormones, including sex hormones, may affect and be affected by the immune system. For example, both estrogen and progesterone, two important female sex hormones, may suppress some immune activity. Testosterone, the primary male hormone, may also act as an immune response suppressor. During pregnancy, estrogen and progesterone levels are very high, which may help explain why pregnant women with MS usually have less disease activity.

Kathryn R. Simpson, author of The MS Solution has attributed MS to hormone insufficiency.  She has a wealth of information in her book that you can get here.  I’ll be studying and applying the principles I learn here and you can too!

Kathryn suggests we find an advisor and advocate while we go through the start-up phase of detecting and treating our endocrine deficiencies.  Finding the right doctor to partner with in this process, she says, will be critical to the success of our therapy. “Nancy Sicotte, MD, Rhonda Voskuhl, MD, and colleagues have published results from a small study, funded by the National MS Society and others, suggesting that one year of treatment with a gel containing the sex hormone testosterone (applied to the skin) in 10 men with relapsing-remitting MS resulted in significant improvements in cognitive function and in slowing brain tissue loss. These positive findings were reported in the May 2007 issue of Archives of Neurology.

I have always believed I, alone, had control over my health, after extensive emotional clearing,  controlling my eating,  all that I’ve believed and still experiencing MS symptoms, I realize there is more to it!  I have to admit,

I always believed I, alone, had control over my health (don’t worry, God is always in the mix), after doing all that I’ve believed and still experiencing MS symptoms, I realize there is more to it! I have more to learn and more to do!  Kathryn Simpson has given me the information to research and apply.

I have to say, I’m a very happy person and I’m sure that faithfully living out all my beliefs has made me the happy person that I am (again, knowing that all of it is because of God). I am completely grateful for everything that I’ve learned.  It will be fun to see where the future takes me! 



that both testosterone and estriol—an estrogen hormone that is produced during late pregnancy has a beneficial effect in experimental allergic encephalomyelitis (EAE), the animal model of MS. Based on these findings, Rhonda Voskuhl, MD, and colleagues conducted a small trial of estriol in women with MS.


Research through the MS Society is being conducted and estriol appeared to reduce MRI activity in women with relapsing remitting MS, but not in those with secondary progressive MS. Dr. Voskuhl is now leading a team of investigators at seven medical centers to conduct a two-year, controlled clinical trial of estriol added to standard therapy to treat MS. Investigators plan to administer either oral estriol along with Copaxone® (glatiramer acetate, Teva Pharmaceutical Industries Ltd.) or Copaxone plus inactive placebo to 130 women with relapsing-remitting MS. If successful, this clinical trial could lay the groundwork for a larger, definitive trial that could lead to a new treatment option for women with MS.”